David achieved his large profits in the slasher horror trilogy Scream (1996), Scream 2 (1998) and Scream 3 (2000) as Deputy Dewey. He as well met his married woman Courteney Cox on the set, & married her around 1999. Their number 1 tike, the girl known as Coco Riley Arquette, was natural around 2004. It use at times as well appeared together within the Coke advertisement on TV in 2003.

He supported John Kerry during the 2004 election.

Arquette is good deal disliked by professional wrestling fans, after he won a WCW World Heavyweight Title on April 25, 2000 in an effort to promote his wrestling-based flick, Ready to Rumble. A storyline was hugely unpopular; potentially though Arquette himself was the wrestling fan, he reportedly thought it was the bad idea. He was sooner or later confident to launder a stunt by head booker Vince Russo. Arquette donated a totality of his WCW remuneration to the families of the late Brian Pillman, Owen Hart and Brian Hildebrand.